Virology MCQs 76-115

76. Traditional vaccination for the common cold is virtually impossible
because there are multiple serotypes of which one of the following viruses?
a. Rabies
b. Rhinovirus
c. Cytomegalovirus
d. Respiratory syncytial virus
e. Mumps






77. Which of the following is available and effective for hepatitis A?
a. Acyclovir
b. Killed virus vaccine
c. Inactivated virus vaccine
d. Live virus vaccine
e. Recombinant viral vaccine





78. Patients should be vaccinated annually for influenza with which of the
following vaccines?
a. Immune serum globulin
b. Killed virus vaccine
c. Inactivated virus vaccine
d. Live virus vaccine
e. Recombinant viral vaccine





79. The vaccine for measles is best characterized as a
a. Bacterin
b. Killed virus vaccine
c. Inactivated virus vaccine
d. Live virus vaccine
e. Recombinant viral vaccine





80. Which one of the following would be the treatment of choice for HSV
infection?
a. Acyclovir
b. Killed virus vaccine
c. Herpes immune globulin
d. Azythromycin
e. Recombinant viral vaccine




81. Which of the following best describes the presently available vaccine
for hepatitis B?
a. Synthetic peptide vaccine
b. Killed virus vaccine
c. Inactivated virus vaccine
d. Live virus vaccine
e. Recombinant viral vaccine






82. Chicken pox is a common disease of childhood. It is caused by which
of the following viruses?
a. Cytomegalovirus
b. Rotavirus
c. Varicella-zoster virus
d. Adenovirus
e. Papillomavirus





83. Excluding influenza, which one of the following viruses is a common
cause of acute respiratory disease?
a. Cytomegalovirus
b. Rotavirus
c. Varicella-zoster virus
d. Adenovirus
e. Papillomavirus





84. Human warts are not only cosmetically unsightly but may lead to cancer
of the cervix. They are caused by which one of the following viruses?
a. Cytomegalovirus
b. Rotavirus
c. Varicella-zoster virus
d. Adenovirus
e. Papillomavirus





85. A vaccine is available for one of the most common causes of infantile
gastroenteritis. However, it has recently been recalled. The virus is
a. Cytomegalovirus
b. Rotavirus
c. Varicella-zoster virus
d. Adenovirus
e. Papillomavirus





86. A child has mononucleosis-like symptoms yet the test for mononucleosis
and the EBV titers are negative. One of the causes of heterophilenegative
mononucleosis is
a. Cytomegalovirus
b. Herpes simplex virus
c. Varicella-zoster virus
d. Adenovirus
e. Coxsackievirus
24 Microbiology





87. Malaise and fatigue with increased “atypical” lymphocytes and a reactive
heterophil antibody test is most commonly caused by
a. Toxoplasma
b. Borrelia burgdorferi
c. Epstein-Barr virus
d. Parvovirus
e. Rubella virus






88. Lethargy, malaise, and fatigue are observed in a patient 2 weeks after
eating raw hamburger at a restaurant. The most likely infectious cause is
a. Toxoplasma
b. Cytomegalovirus
c. E. coli
d. Salmonella
e. Clostridium





89. Burkitt’s lymphoma is characterized by elevated “early antigen” tests
with a restricted pattern of fluorescence. This disease is caused by
a. Cytomegalovirus
b. B. burgdorferi
c. Epstein-Barr virus
d. Lymphogranuloma venereum
e. Herpes simplex virus






90. This virus may be detected by the polymerase chain reaction (PCR) in
a variety of cells of patients with nasopharyngeal carcinoma.
a. Measles
b. Mumps
c. Rubella
d. Parvovirus
e. Epstein-Barr virus






91. This virus causes a mononucleosis-like syndrome caused by a latent
herpesvirus; it is often a congenital infection. Large amounts of the virus
are excreted in the urine; thus, urine becomes the fluid of choice for diagnosis
of this disease.
a. Epstein-Barr virus
b. Cytomegalovirus
c. HHV-6
d. Parvovirus
e. Norwalk virus





Questions 92–96



Assume you are asked by a resident what the most appropriate specimen is
for the detection of a particular virus.



92. Human papillomavirus
a. Cervical tissue
b. Synovial fluid
c. Blood
d. Skin




93. Cytomegalovirus
a. Cervical tissue
b. Synovial fluid
c. Blood
d. Skin
e. Cerebrospinal fluid




94. Enterovirus
a. Cervical tissue
b. Synovial fluid
c. Blood
d. Skin
e. Cerebrospinal fluid






95. Varicella-zoster virus (VZV)
a. Cervical tissue
b. Synovial fluid
c. Blood
d. Skin
e. Cerebrospinal fluid





96. Adenovirus 40/41
a. Cervical tissue
b. Synovial fluid
c. Blood
d. Stool
e. Cerebrospinal fluid





97. Which of the following is transmitted by the fecal-oral route; can be
acquired from shellfish; and often causes acute jaundice, diarrhea, and liver
function abnormalities?
a. Rotavirus
b. Adenovirus 40/41
c. Norwalk virus
d. Astrovirus
e. Hepatitis A virus





98. Which of the following is the second most common cause of pediatric
gastroenteritis? Unlike other similar viruses, this virus causes only gastroenteritis.
a. Rotavirus
b. Adenovirus 40/41
c. Norwalk virus
d. Astrovirus
e. Hepatitis A virus




99. Which of the following is the most common cause of pediatric gastroenteritis?
It is difficult to grow in cell culture but can be detected easily
by immunologic methods (ELISA).
a. Rotavirus
b. Adenovirus 40/41
c. Norwalk virus
d. Astrovirus
e. Hepatitis A virus






100. Which of the following is a common cause of epidemic gastroenteritis,
particularly aboard cruise ships and in summer camps? It may be
detected by ELISA methods or electron microscopy.
a. Rotavirus
b. Adenovirus 40/41
c. Norwalk virus
d. Astrovirus
e. Hepatitis A virus





101. Which of the following is a cause of mild gastroenteritis? It can be
transmitted by the fecal-oral route but not by food consumption.
a. Rotavirus
b. Adenovirus 40/41
c. Norwalk virus
d. Astrovirus
e. Hepatitis A virus






102. IgM antibody to the viral particle is the method of choice for laboratory
diagnosis of which one of the following hepatitis viruses?
a. Hepatitis A
b. Hepatitis B
c. Hepatitis C
d. Hepatitis D
e. Hepatitis E






103. This virus belongs to the family of flaviviruses and its reservoir is
strictly human. Transmission is blood-borne so the blood supply is routinely
screened for this virus.
a. Hepatitis A
b. Hepatitis B
c. Hepatitis C
d. Hepatitis D
e. Hepatitis E







104. Vaccination for this hepatic disease is with viral surface antigen and
usually provides immunity.
a. Hepatitis A
b. Hepatitis B
c. Hepatitis C
d. Hepatitis D
e. Hepatitis E





105. This hepatitis virus is a calicivirus. The reservoir is in pigs, and
humans acquire it via the fecal-oral route.
a. Hepatitis A
b. Hepatitis B
c. Hepatitis C
d. Hepatitis D
e. Hepatitis E





106. This hepatitis virus is a defective virus in that it cannot replicate
independently without the presence of hepatitis B virus.
a. Hepatitis A
b. Hepatitis B
c. Hepatitis C
d. Hepatitis D
e. Hepatitis E






107. Which of the following is the causative agent of a variety of cutaneous
warts (plantar, common, and flat) and is associated with cervical neoplasia?
a. Human papillomavirus
b. West Nile virus
c. Tick-borne encephalitis virus
d. Polyomavirus
e. Subacute sclerosing panencephalitis virus (SSPE)







108. Recently appearing in the United States, this virus is carried by birds,
transmitted by mosquitoes, and infects humans and horses.
a. Human papillomavirus
b. West Nile virus
c. Tick-borne encephalitis virus
d. Polyomavirus
e. SSPE






109. Which of the following viruses causes progressive multifocal
leukoencephalopathy (PML), a disease causing demyelination in the central
nervous system?
a. Human papillomavirus
b. West Nile virus
c. Tick-borne encephalitis virus
d. Polyomavirus
e. SSPE







110. This virus is transmitted by the same arthropod that transmits
babesiosis and ehrlichiosis.
a. Human papillomavirus
b. West Nile virus
c. Tick-borne encephalitis virus
d. Polyomavirus
e. SSPE






111. This virus is a single-stranded RNA orthomyxovirus. Annual vaccination
is necessary because of antigenic drift and shift.
a. Measles virus
b. Influenza virus
c. Respiratory syncytial virus
d. Parainfluenza virus
e. Adenovirus






112. This virus is a single-stranded RNA paramyxovirus. The rash known
as Koplik’s spots is pathognomonic.
a. Measles virus
b. Influenza virus
c. Respiratory syncytial virus
d. Parainfluenza virus
e. Adenovirus







113. This virus is the leading cause of bronchiolitis and communityacquired
pneumonia in infants.
a. Measles virus
b. Influenza virus
c. Respiratory syncytial virus
d. Parainfluenza virus
e. Adenovirus






114. This is a paramyxovirus and causes the syndrome known as croup.
a. Measles virus
b. Influenza virus
c. Respiratory syncytial virus
d. Parainfluenza virus
e. Adenovirus







115. This is a double-stranded DNA virus. It is responsible for 15% of
pediatric respiratory infections and 10 to 15% of acute diarrhea in children.
a. Measles virus
b. Influenza virus
c. Respiratory syncytial virus
d. Parainfluenza virus
e. Adenovirus