Virology MCQs 51-75

51. Cytomegalovirus (CMV) infection is common. Which one of the following
statements best characterizes CMV?
a. It can be transmitted across the placental barrier
b. While a common infection, CMV is almost always symptomatic
c. The CMV can be cultured from red blood cells of infected patients
d. Unlike other viral infections, CMV is not activated by immunosuppressive therapy
e. There is no specific therapy for CMV





52. Human rotaviruses are characterized by which of the following statements?
a. They produce an infection that is primarily seen in adults
b. They produce cytopathic effects in many conventional tissue culture systems
c. They are lipid-containing RNA viruses possessing a double-shelled capsid
d. They can be sensitively and rapidly detected in stools by the enzyme-linked
immunosorbent assay (ELISA) technique
e. They have been implicated as a major etiologic agent of infantile respiratory disease





53. Subacute sclerosing panencephalitis virus (SSPE) is best described by
which of the following statements?
a. It is a progressive disease involving both white and gray matter
b. It is a late CNS manifestation of mumps
c. It is a common event occurring in 1 of 300,000 cases of mumps
d. Viral DNA can be demonstrated in brain cells
e. Demyelination is characteristic





54. Rotavirus is a double-stranded RNA virus with a double-walled capsid.
Which one of the following statements best describes rotavirus?
a. There are no related animal viruses
b. It is a major cause of neonatal diarrhea
c. It is readily cultured from the stool of infected persons
d. Maternal antibody does not appear to be protective
e. Early breast-feeding offers no protection to neonates against it






55. Paramyxoviruses are most commonly associated with which of the following
diseases?
a. Fifth disease
b. Rubella
c. Croup
d. Tonsillitis
e. Otitis media





56. Human papillomavirus is most commonly associated with
a. Rectal polyps
b. Prostate cancer
c. Condyloma acuminatum
d. Hepatic carcinoma
e. Carcinoma of the lung





57. Reverse transcriptase is an enzyme unique to the retroviruses. Which
one of the following is a function of the enzyme reverse transcriptase?
a. DNase activity
b. RNA-dependent RNA polymerase activity
c. RNA isomerase activity
d. RNA-dependent DNA polymerase activity
e. Integration activity





58. St. Louis encephalitis, a viral infection, was first recognized as an
entity in 1933. Which of the following best describes SLE?
a. It is transmitted to humans by the bite of an infected tick
b. It is caused by a togavirus
c. It is the major arboviral cause of central nervous system infection in the United
States
d. It may present initially with symptoms similar to influenza
e. Laboratory diagnosis is routinely made by cultural methods






59. There is considerable overlap of signs and symptoms seen in congenital
and perinatal infections. In a neonate with “classic” symptoms of congenital
cytomegalovirus (CMV) infection, which one of the following tests
would be most useful in establishing a diagnosis?
a. CMV IgG titer on neonate’s serum at birth
b. CMV IgG titer on mother’s serum at birth of infant
c. CMV IgM titer on neonate’s serum at birth and at 1 month of age
d. Total IgM on neonate’s serum at birth
e. Culture of mother’s urine





60. Interferon, a protein that inhibits viral replication, is produced by cells
in tissue culture when the cells are stimulated with which of the following?
a. Botulinum toxin
b. Synthetic polypeptides
c. Viruses
d. Chlamydiae
e. Gram-positive bacteria






61. Which one of the following statements best describes the cytopathic
effects of viruses on host cells?
a. Usually morphological in nature
b. Often associated with changes in mitochondrial membranes
c. Pathognomonic for an infecting virus
d. Rarely fatal to the host cell
e. Can only be seen with an electron microscope





62. A 17-year-old girl presents with cervical lymphadenopathy, fever, and
pharyngitis. Infectious mononucleosis is suspected. The most rapid and
clinically useful test to make this diagnosis is
a. IgM antibody to viral core antigen (VCA)
b. IgG antibody to VCA
c. Antibody to Epstein-Barr nuclear antigen (EBNA)
d. Culture
e. C reactive protein (CRP)





63. Which one of the following viruses would be most likely to establish a
latent infection?
a. Adenovirus
b. Measles virus
c. Influenza virus
d. Parvovirus
e. Coxsackievirus group B





64. A regimen that includes appropriately administered gamma globulin
may be contraindicated in which one of the following diseases?
a. Hepatitis A
b. Hepatitis B
c. Rabies
d. Poliomyelitis
e. Infectious mononucleosis





65. Atypical lymphocytosis is most likely to be found in which one of the
following diseases?
a. Encephalitis caused by herpes simplex virus (HSV)
b. Mononucleosis induced by Epstein-Barr virus
c. Parvovirus infection
d. Chronic hepatitis C
e. Rotavirus gastroenteritis





66. A patient has arthralgia, a rash, lymphadenopathy, pneumonia but no
fever. Which of the following diseases is most likely based on these symptoms?
a. Dengue fever
b. St. Louis encephalitis
c. Infectious mononucleosis
d. Hepatitis
e. HIV infection






67. Hepatitis C (HCV) is usually a clinically mild disease, with only minimal
elevation of liver enzymes. Hospitalization is unusual. Which one of
the following statements best characterizes HCV?
a. Few cases progress to chronic liver disease
b. It often occurs in posttransfusion patients
c. HBV but not HCV infections occur in IV drug abusers
d. It is a DNA virus
e. Blood products are not tested for antibody to HCV





68. Which of the following markers is usually the first viral marker
detected after hepatitis B infection?
a. HBeAg
b. HBsAg
c. HBcAg
d. Anti-HBc
e. HbeAb




69. Which of the following may be the only detectable serological marker
during the early convalescent phase of HBV infection (window phase)?
a. HBeAg
b. HBsAg
c. HBcAg
d. Anti-HBc
e. HbeAb





70. Which one of the following markers is closely associated with HBV
infectivity and DNA polymerase activity?
a. HBeAg
b. HBsAg
c. HBcAg
d. Anti-HBc
e. HBeAb




71. Which of the following is found within the nuclei of infected hepatocytes
and not usually in the peripheral circulation?
a. HBeAg
b. HBsAg
c. HBcAg
d. Anti-HBc
e. HbeAb






72. Which one of the following viruses is the leading cause of congenital
malformations?
a. Rabies
b. Rhinovirus
c. Cytomegalovirus
d. Respiratory syncytial virus
e. Mumps




73. Orchitis, which may cause sterility, is a possible manifestation of
which of the following?
a. Rabies
b. Rhinovirus
c. Cytomegalovirus
d. Respiratory syncytial virus
e. Mumps




74. Which of the following is a leading cause of pneumonia primarily in
infants?
a. Rabies
b. Rhinovirus
c. Cytomegalovirus
d. Respiratory syncytial virus
e. Mumps





75. Which of the following causes a fatal encephalitis for which a vaccine
is available?
a. Rabies
b. Rhinovirus
c. Cytomegalovirus
d. Respiratory syncytial virus
e. Mumps